Jaka Kragelj | Postdoctoral Scholar

Jaka Kragelj obtained a B.S and M.S. degrees in Biochemistry at the University of Ljubljana in Slovenia in 2011. He studied phospholipase PLA2 enzymes under the supervision of prof. Igor Križaj.  After studying intrinsically disordered proteins during a 3 months internship in Dr. Edward Lemke’s lab at the EMBL in Heidelberg, Jaka joined Dr. Martin Blackledge’s laboratory at University of Grenoble Alpes. For his graduate thesis Jaka characterized the structural ensemble of an intrinsically disordered region of a MAPK kinase, inspected its interaction with the downstream MAP-kinase and described the dynamics of the interaction between the two.  In 2015 he joined Rama Ranganathan’s lab at the UT Southwestern to determine differences between natural and computationally designed proteins.

He joined Dr. Kendra Frederick’s lab in October 2017 and is currently investigating protein conformations in live cells.


2011 Marie Curie fellowship (3 years), European Union Framework Programme 7

2011 Award for Outstanding Master’s Thesis, Faculty of Chemistry and Chemical Technology, University of Ljubljana


Ensemble Calculation for Intrinsically Disordered Proteins Using NMR Parameters.
Kragelj, J., Blackledge, M., Jensen, M.R.
Adv Exp Med Biol. 870: 123-47. (2015)

Structure and dynamics of the MKK7-JNK signaling complex
Kragelj, J., Palencia, A., Nanao, M., Damien, M., Bouvignies, G., Blackledge, M., & Jensen, M.R.
Proc Natl Acad Sci U S A112: 3409-14. (2015)

Visualizing the molecular recognition trajectory of an intrinsically disordered protein.
Schneider, R., Maurin, D., Communie, G., Kragelj, J., Hansen, D. F., Ruigrok, R., Jensen, M.R., & Blackledge, M.
J Am Chem Soc. 137: 1220-9. (2015)

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Krishna, N,, Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., Jensen, M. R., Gauss, C. M., Page, R., Blackledge, M., Muthuswamy, S. K., Peti, W., & Tonks N.K.
Nat Chem Biol. 10:558-66. (2014)

Small-angle X-ray scattering and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2.
Sterckx, Y. G., Volkov, A. N., Vranken, W. F., Kragelj, J., Jensen, M. R., Buts, L., Garcia-Pino, A., Jové, T., Van Melderen, L., Blackledge, M., van Nuland, N. A., & Loris, R.
Structure. 22(6):854-65. (2014)

Conformational propensities of intrinsically disordered proteins from NMR chemical shifts.
Kragelj, J., Ozenne, V., Blackledge, M., & Jensen, M. R.
Chemphyschem. 14:3034-45. (2013)